A TerminaTOR of mTORC1 signaling
A genetically encodable and targetable protein fragment derived from PRAS40 inhibits mTOR complex 1 (mTORC1) signaling in a compartment-specific manner.
This innovative tool will enable researchers to address whether different subcellular pools of mTORC1 control distinct cellular processes. The authors report a genetically encodable and targetable protein fragment derived from PRAS40 that inhibits mTORC1 signaling in a compartment-specific manner. This discovery has significant implications for understanding the regulation of mTORC1 in various cellular contexts.