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TB-500 (Thymosin Beta-4)

Thymosin β4 fragment · actin-binding research

Injectable 5mcg, custom custom PRECLINICAL

Overview

What is TB-500 (Thymosin Beta-4)?

TB-500 is the research name commonly used for a synthetic fragment of thymosin beta-4, an actin-sequestering peptide involved in cell migration and cytoskeletal remodeling. All catalog material is for laboratory research use only.

Key Benefits

Actin cytoskeleton, Cell migration assays, Soft-tissue models

Mechanism of Action

Thymosin β4 binds G-actin and is studied for endothelial migration, wound-closure assays, and cardiac-repair models. TB-500 preparations are sold as research fragments, not as licensed thymosin drugs.

Molecular Information

Weight
4921.0 g/mol
Length
37 amino acids
Type
Thymosin Beta-4 (TB-500 is the synthetic commercial fragment)
Formula
C212H350N56O78S
Amino Acid Sequence Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Ile-Glu-Ile-Lys-Gln-Ala-Gly-Glu-Ser-His-Gly-Ser-Gly-Lys-Val-Val-Pro-Ala-Asp-Ala

Research directions

Repair biology Preclinical

  • Migration and angiogenesis readouts

Pharmacokinetics

Peak hours (parenteral models)
Half-life hours (fragment-dependent)
Cleared within a day in typical models

Literature PK is sparse and fragment-specific.

Literature

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