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5-Amino-1MQ

NNMT inhibitor · metabolic & NAD+ research

Oral 50–75 mg Once daily with food CORE

Overview

What is 5-Amino-1MQ?

5-Amino-1MQ is a small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor used in metabolic and cellular-energy research. Inhibiting NNMT is studied as a way to preserve NAD+ pools that otherwise drain through methylation of nicotinamide. All catalog material is for laboratory research use only.

Key Benefits

Enhanced NAD+ levels, improved mitochondrial function, longevity research interest, better energy metabolism, enhanced cellular repair, improved insulin sensitivity, convenient daily oral dosing.

Mechanism of Action

The compound occupies the NNMT active site, reducing conversion of nicotinamide to 1-methylnicotinamide. Higher available nicotinamide can feed NAD+ salvage, which in models is linked to sirtuin activity and mitochondrial output. It is not a peptide; research formats are typically oral small-molecule preparations.

Quick Start Guide

Typical Dose 50–75 mg
How Often Once daily with food
Where to Inject Oral — not injected
Injection Timing With food, same time each day
Effects Timeline Energy: 1–2 weeks, Metabolic: 4–8 weeks, Longevity markers: 8–12 weeks
Storage Room temperature, dry and protected from light
Cycle Length 8–12 weeks
Break Between 4 weeks off is commonly discussed

Molecular Information

Weight: 188.23 g/mol
Length: Small molecule (not a peptide)
Type: NNMT inhibitor
Formula: C11H12N2

Amino Acid Sequence — (small-molecule research compound, not a linear peptide)

Research directions

Cellular energy Core

NAD+ availability after NNMT block
Mitochondrial function markers

Metabolic models Active

Adipocyte size and insulin-sensitivity assays

Pharmacokinetics

Peak ~45–60 min (preclinical oral)

Half-life ~7–8 h oral (rodent PK)

Cleared about 1–2 days (models)

Rodent PK only. Not a human protocol.

Literature

Neelakantan et al., NNMT inhibition in obese mice — 2018 · Animal. Diet-induced obesity models after NNMT inhibition.
Oral PK of 5-amino-1MQ (rat) — 2021 · PK. Oral bioavailability and half-life in rats.