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BPC-157

Gastric pentadecapeptide · tissue-repair research

Injectable 250–500 mcg Once or twice daily EXTENSIVE PRECLINICAL

Overview

What is BPC-157?

BPC-157 is a synthetic 15-residue fragment related to a protective protein described in gastric juice. It is one of the most cited research peptides for angiogenesis, gut-barrier, and soft-tissue models. It is not an approved medicine. All catalog material is for laboratory research use only.

Key Benefits

Tissue-repair and angiogenesis models, GI mucosal protection papers, tendon/ligament research interest, widely co-cited with TB-500 in recovery literature.

Mechanism of Action

Proposed mechanisms in the literature include nitric-oxide system modulation, growth-factor receptor crosstalk (including VEGFR2 in some papers), and effects on FAK-paxillin signaling in fibroblasts. Routes in papers vary (parenteral vs oral); that is experimental design, not a use instruction.

Molecular Information

Weight
1419.5 g/mol
Length
15 amino acids
Type
Gastric pentadecapeptide
Formula
C62H98N16O22
Amino Acid Sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Leu

Research directions

Musculoskeletal models Extensive preclinical

  • Tendon, ligament, and muscle injury assays

GI barrier Preclinical

  • NSAID and fistula-type models in animals

Pharmacokinetics

Peak rapid in parenteral models
Half-life short peptide (minutes–hours, model-dependent)
Cleared hours in typical peptide PK

Peptide PK is model- and route-dependent.

Literature

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