Analysis of the factors affecting the quality of life in patients with pituitary adenomas before and after end

Pituitary adenomas (PAs) cause physiological and psychological symptoms, leading to a decline in quality of life (QOL). This study identifies factors influencing QOL in patients with PAs before and after endoscopic transsphenoidal surgery (ETSS).

A total of 83 patients with PAs who underwent ETSS and completed questionnaires preoperatively and at 1/3 months postoperatively were recruited. They were divided into four groups based on preoperative HR-QOL scores. The study used comparative and regressive analysis to identify factors correlated with QOL impairment before ETSS and improvement after ETSS.

The degree of physiological QOL impairment was positively correlated with visual-related QOL (VR-QOL) and negatively correlated with headache impact test (HIT-6) and Hamilton anxiety/depression rating scale (HAMA) scores. Psychological QOL impairment was positively correlated with age and negatively correlated with HIT-6, HAMA, and HAMD scores. After ETSS, patients showed gradual improvements in physiological and psychological QOL, positively correlated with increased VR-QOL and decreased HIT-6, HAMA, and HAMD scores.

The impairment of HR-QOL before ETSS and the improvement of HR-QOL after ETSS in patients with PAs were closely correlated with headache, subjective perception of vision, and visual field loss, as well as anxiety/depression emotions.