eHealth Lifestyle Interventions for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Systematic Review

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing health concern, particularly among adults. eHealth lifestyle interventions have emerged as promising management strategies for this condition. A systematic review was conducted to synthesize the most recent evidence on the effectiveness of eHealth lifestyle interventions in adults with MASLD. Twelve databases were searched from inception to April 2, 2025, and a total of 22 trials (13 randomized controlled trials and 9 quasi-experimental trials) comprising 2579 adult patients with MASLD were included. The intervention components identified were goal setting, health education, consultation, self- and device-monitoring, feedback, patient reminders, and social support. Meta-analysis of the randomized controlled trials demonstrated that eHealth lifestyle interventions were significantly superior to standard care in reducing weight, body mass index, waist circumference, alanine aminotransferase, aspartate aminotransferase, and γ-glutamyl transferase levels, and improving MASLD status. Improvements in self-management, dietary adherence, physical activity, exercise, and quality of life were also observed. The findings suggest that eHealth lifestyle interventions are a viable option for managing MASLD, offering precise and scalable management strategies. However, it is essential to note that the current evidence base is limited, and further research is needed to fully understand the effects of eHealth lifestyle interventions on MASLD outcomes.