How ocean enzymes are providing access to understudied cannabinoids
The berberine-bridge-like (BBE-like) enzyme family catalyzes diverse chemical transformations, including the final step in cannabinoid biosynthesis, yet the molecular basis of these activities is not broadly understood. Combining structural, biochemical and biophysical approaches, we expose the complexities in how two marine bacterial BBE-like enzymes generate the understudied phytocannabinoid can
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The berberine-bridge-like (BBE-like) enzyme family catalyzes diverse chemical transformations, including the final step in cannabinoid biosynthesis, yet the molecular basis of these activities is not broadly understood. Combining structural, biochemical and biophysical approaches, we expose the complexities in how two marine bacterial BBE-like enzymes generate the understudied phytocannabinoid cannabichromenic acid.
Tjallinks, G., Mattevi, A. & Fraaije, M. W. Biosynthetic strategies of berberine bridge enzyme-like flavoprotein oxidases toward structural diversification in natural product biosynthesis. Biochemistry 63, 2089–2110 (2024). A review article that describes the various chemical reactions BBE-like enzymes perform in the biosynthesis of natural products.