Maladaptive trained immunity as a hematopoietic stem cell driver of inflammaging
A new study reveals that aging hematopoietic stem cells trigger a form of innate immune memory, known as trained immunity, that fuels the chronic low-grade inflammation that underlies age-related physiological decline. SIRT3, a mitochondrial deacetylase whose expression wanes with age, emerges as a key molecular brake on this process.
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A new study reveals that aging hematopoietic stem cells trigger a form of innate immune memory, known as trained immunity, that fuels the chronic low-grade inflammation that underlies age-related physiological decline. SIRT3, a mitochondrial deacetylase whose expression wanes with age, emerges as a key molecular brake on this process.
M.D. is funded by Canadian Institute of Health Research (CIHR), National Sanitarium Association (NSA), and Novo Nordisk Foundation, a Canada Research Chairs in Trained Immunity, and a McGill Interdisciplinary Initiative in Infection and Immunity (MI4) Grant. M.D. holds the Canada Research Chair in Trained Immunity, the Strauss Chair in Respiratory Diseases and is a fellow member of the Royal Society of Canada. K.Y.K. is funded by grants from the National Institutes of Health R35HL155672 and P01CA265748.