TogoPhosTAC as a delivery-ready platform for targeted protein dephosphorylation
This study presents togoPhosTAC, a biologic platform that directs engineered phosphatases to target proteins for phosphate removal, reducing pathological tau phosphorylation and alleviating behavioral deficits in male PS19 tauopathy mice.
This study presents togoPhosTAC, a biologic platform that directs engineered phosphatases to target proteins for phosphate removal, reducing pathological tau phosphorylation and alleviating behavioral deficits in male PS19 tauopathy mice.