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Prediabetes increases the risk of progression to type 2 diabetes (T2DM). This study evaluated the efficacy of a mobile application-based lifestyle intervention compared with standard care in individuals with prediabetes. In this open-label randomized controlled trial, healthcare personnel with prediabetes at a tertiary-care hospital in Bangkok, Thailand, were randomly assigned to either a mobile application–based intervention or standard care. The primary outcome was the between-group difference in fasting plasma glucose (FPG) at 6 months. Secondary outcomes included anthropometric measures, metabolic parameters, patient-reported outcomes and reversion from prediabetes to normoglycemia. A total of 136 participants were randomized to the application group (n = 69) or standard care group (n = 67); 131 participants were included in the analysis. Mean age was 45.9 ± 9.5 years, and 77.1% were female. At 6 months, predicted mean FPG was lower in the application group than in the standard care group, with a mean difference of -2.80 mg/dL (95% CI -5.00 to -0.59; P = 0.01). HbA1c was also lower in the application group (mean difference − 0.10%, 95% CI -0.16 to -0.05; P < 0.001). In addition, the application group showed greater reductions in body weight, waist circumference, body fat percentage, and body fat mass. Reversion to normoglycemia at 6 months was more frequent in the application group than in the standard care group (17.19% vs. 5.97%; P = 0.047). No significant between-group differences were observed for blood pressure, lipid parameters, 2-h oral glucose tolerance test glucose, fasting insulin, HOMA indices, or patient-reported outcomes. A mobile application–based lifestyle intervention was associated with modest but significant improvements in fasting glycaemia and adiposity-related outcomes, together with a higher likelihood of reversion to normoglycemia at 6 months.