What is KPV?
KPV is the C-terminal tripeptide of α-MSH (Lys-Pro-Val). It retains anti-inflammatory signaling in many models without the full pigment activity of α-MSH. All catalog material is for laboratory research use only.
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KPV
α-MSH anti-inflammatory tripeptide
Injectable
200–500 mcg
Once or twice daily
PRECLINICAL
Overview
Key Benefits
NF-κB / inflammatory models, colitis and keratinocyte papers, skin and gut research, often added to Glow to make KLOW.
Mechanism of Action
It is studied in colitis, keratinocyte, and innate-immunity assays, including intracellular uptake via PepT1 in some gut papers.
Molecular Information
- Weight
- 342.4 g/mol
- Length
- 3 amino acids
- Type
- α-MSH anti-inflammatory tripeptide
- Formula
- C16H30N4O4
Amino Acid Sequence
Lys-Pro-Val
Research directions
Inflammation Preclinical
- Colitis and skin inflammation models
Pharmacokinetics
Peak local models dominate
Half-life short tripeptide
Cleared rapid
Often studied locally rather than systemically.
Literature
- KPV inflammatory bowel models — 2008 · Animal. α-MSH tripeptide in gut inflammation.