SS-31

Elamipretide · mitochondrial inner membrane

Injectable 5–10 mg (research); clinical programs used higher IV/SC amounts Once daily EXTENSIVE PRECLINICAL + TRIALS

Overview

What is SS-31?

SS-31 (elamipretide) is an aromatic-cationic tetrapeptide that associates with cardiolipin on the inner mitochondrial membrane. It has been in multiple clinical programs for mitochondrial and cardiac indications; research vials are not those drug products. All catalog material is for laboratory research use only.

Key Benefits

Cardiolipin-targeted tetrapeptide, bioenergetics assays, clinical-development molecule (elamipretide) exists separately from research vials.

Mechanism of Action

Binding cardiolipin is proposed to stabilize cristae architecture and electron-transport efficiency, reducing ROS in stressed mitochondria.

Quick Start Guide

Typical Dose 5–10 mg (research); clinical programs used higher IV/SC amounts
How Often Once daily
Where to Inject SubQ abdomen or thigh (research); IV in some clinical PK
Injection Timing Once daily, timing less critical than consistency
Effects Timeline Bioenergetic markers can move in days; organ programs run weeks
Storage Refrigerate; protect from light
Cycle Length Application-dependent (days to weeks in papers)
Break Between Not standardized

Molecular Information

Weight: 639.7 g/mol
Length: 4 amino acids
Type: Mitochondria-targeted tetrapeptide
Formula: C32H45N7O5

Amino Acid Sequence D-Arg-Dmt-Lys-Phe-NH2 (elamipretide; Dmt = 2,6-dimethyltyrosine)

Research directions

Bioenergetics Extensive preclinical + trials

Mitochondrial disease and cardiac programs

Pharmacokinetics

Peak minutes–hours IV/SC in clinical PK

Half-life hours (elamipretide programs)

Cleared within a day typical

Clinical PK of elamipretide programs.

Literature

Szeto-Schiller peptides — 2014 · Review. Mitochondria-targeted peptides.