Reevaluating the Role of NAD+ in Cellular Metabolism: A Review of Current Studies
NAD+ (Nicotinamide adenine dinucleotide) is a crucial cofactor in various cellular processes, including energy metabolism, DNA repair, and epigenetic regulation. Despite its well-established importance, recent studies ha
NAD+ is a vital molecule that plays a central role in maintaining cellular homeostasis. As a cofactor in energy metabolism, NAD+ is essential for the functioning of the electron transport chain, which generates energy for cells through the process of oxidative phosphorylation. In addition to its role in energy metabolism, NAD+ is also involved in DNA repair and epigenetic regulation, making it a key player in maintaining genome stability and regulating gene expression. However, recent studies have raised questions about the significance of NAD+ in human health and disease. Some research has suggested that NAD+ may have a protective role in certain diseases, such as Alzheimer's and Parkinson's, while other studies have found no association between NAD+ levels and disease outcomes. This review aims to summarize the current state of knowledge on NAD+ and its role in cellular metabolism, highlighting the findings of recent studies and their implications for our understanding of NAD+ biology.