Unveiling the Hidden Role of NAD+ in Mitochondrial Function and Disease Pathogenesis
NAD+ (Nicotinamide adenine dinucleotide) is a crucial cofactor in energy metabolism, yet its involvement in mitochondrial function and disease pathogenesis remains poorly understood. This review aims to elucidate the pre
NAD+ is a vital molecule that plays a central role in energy metabolism, serving as a cofactor for numerous enzymatic reactions involved in cellular respiration, biosynthesis, and DNA repair. While its well-established functions in these processes are well-documented, recent studies have begun to uncover a previously overlooked role of NAD+ in regulating mitochondrial dynamics, biogenesis, and function. This review aims to provide an overview of the current state of knowledge on NAD+-mediated mitochondrial regulation and its implications in various diseases.