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Adipotide

Prohibitin-targeting peptide (CKGGRAKDC-GG-D(KLAKLAK)2)

Injectable 25mcg, Once daily Once daily ANIMAL / EARLY HUMAN ATTEMPT

Overview

What is Adipotide?

Adipotide is an experimental peptidomimetic designed to target prohibitin in white-adipose vasculature and deliver a pro-apoptotic motif. Early primate work was notable; human development did not yield an approved drug and safety concerns were significant. All catalog material is for laboratory research use only.

Key Benefits

Targeted pro-apoptotic peptide, Adipose-vasculature homing, Not an approved therapy

Mechanism of Action

Homes to adipose vasculature via a targeting sequence, then disrupts mitochondrial membranes of targeted cells — a binary toxin-peptide design, not a hormone analogue.

Molecular Information

Weight
2611.3 g/mol
Length
13 amino acids
Type
Adipotide
Formula
C111H185N35O28S2
Amino Acid Sequence Cys-Lys-Lys-Gly-Arg-Lys-Lys-Cys-Gly-Tyr-Glu (disulfide: Cys¹–Cys⁹)

Research directions

Adipose ablation models Animal / early human attempt

  • White-fat vasculature targeting

Pharmacokinetics

Peak experimental
Half-life not standardized for catalog research
Cleared unknown commercially

Sparse public PK; research interest only.

Literature

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