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AOD9604

HGH fragment 176–191

Injectable 4mcg, Once daily Once daily PRECLINICAL + MIXED TRIALS

Overview

What is AOD9604?

AOD9604 is a modified C-terminal fragment of hGH (residues 176–191) developed to isolate metabolic actions from the full hormone’s IGF-1 growth effects. Clinical lipolysis programs did not lead to a widely marketed drug. All catalog material is for laboratory research use only.

Key Benefits

hGH C-terminal fragment, Lipolysis-focused design, Limited late-stage success

Mechanism of Action

The fragment is studied for lipolytic and anti-lipogenic signaling without the full GH receptor’s growth program — results in humans were modest relative to early hopes.

Molecular Information

Weight
1815.1 g/mol
Length
48 amino acids
Type
Anti-Obesity Drug 9604 (hGH Fragment 177-191)
Formula
C78H125N23O23S
Amino Acid Sequence HGH fragment 177–191 (17 aa; lipolytic domain of human growth hormone)

Research directions

Adipose models Preclinical + mixed trials

  • Lipolysis without IGF-1 rise (design goal)

Pharmacokinetics

Peak hours (oral/SC development forms varied)
Half-life short–moderate
Cleared hours

Several formulations were tested.

Literature

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