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MOTS-c

Mitochondrial-encoded 16-aa peptide

Injectable 5–15 mg Daily or 3× weekly MOUSE

Overview

What is MOTS-c?

MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial 12S rRNA region. It is studied as a mitokine that can translocate to the nucleus under metabolic stress. All catalog material is for laboratory research use only.

Key Benefits

AMPK-related metabolic models, insulin-sensitivity papers in aged mice, exercise-related metabolic flexibility, nuclear translocation under metabolic stress.

Mechanism of Action

Published work links MOTS-c to the folate-AICAR-AMPK axis, insulin sensitivity in aged mice, and exercise-related metabolic flexibility. Human interventional evidence is still limited.

Quick Start Guide

Typical Dose 5–15 mg
How Often Daily or 3× weekly
Where to Inject Abdomen or thigh
Injection Timing Morning or pre-activity in research reports
Effects Timeline Metabolic readouts over 2–4 weeks in animal literature
Storage Lyophilized freeze or refrigerate; reconstituted 2–8°C
Cycle Length 4–8 weeks
Break Between 2–4 weeks

Molecular Information

Weight: 2174.5 g/mol
Length: 16 amino acids
Type: Mitochondrial-derived peptide (MDP)
Formula: C101H152N28O22S2

Amino Acid Sequence MRWQEMGYIFYPRKLR (mitochondrial-derived peptide)

Research directions

Insulin sensitivity Mouse

Aged and diet-challenge models

Exercise biology Emerging

Metabolic flexibility papers

Pharmacokinetics

Peak hours (parenteral models)

Half-life short peptide

Cleared hours

Mostly murine pharmacology.

Literature

Lee et al., MOTS-c — 2015 · Animal. Mitochondrial peptide and metabolism.