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PEG-MGF

Pegylated mechano growth factor

Injectable 2mcg, biweekly biweekly PRECLINICAL

Overview

What is PEG-MGF?

Mechano growth factor is an IGF-1 splice variant (IGF-1Ec in humans) associated with muscle repair after load. Pegylation is used in research catalogs to extend circulating time of a synthetic MGF analogue. All catalog material is for laboratory research use only.

Key Benefits

IGF-1 splice analogue, Muscle-load biology, Pegylated research reagent

Mechanism of Action

MGF is studied for satellite-cell and local repair signaling distinct from liver IGF-1. Pegylated research reagents are not approved doping or drug products; WADA status for IGF-related peptides is prohibited in sport.

Molecular Information

Weight
PEG conjugate — see CoA
Length
12 amino acids
Type
PEG-MGF
Formula
Amino Acid Sequence PEGylated Mechano Growth Factor (E-domain) analog — structure per lot CoA

Research directions

Muscle models Preclinical

  • Load-induced IGF-1Ec literature

Pharmacokinetics

Peak hours (PEG extends vs native)
Half-life hours–longer with PEG
Cleared within a day–days

PEG changes kinetics vs native MGF.

Literature

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