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Retatrutide

Triple GIP/GLP-1/glucagon agonist · metabolic research

Injectable Trial programs used weekly titration (not a vial protocol) Once weekly in clinical-development reports PHASE 2 PUBLISHED

Overview

What is Retatrutide?

Retatrutide is an investigational triple agonist at GIP, GLP-1, and glucagon receptors. Phase 2 obesity-trial data (NEJM) reported large mean weight-change figures in a clinical-development setting. Shop vials are research materials, not a licensed drug product. All catalog material is for laboratory research use only.

Key Benefits

Triple incretin/glucagon pharmacology, large phase-2 weight-change signals (mid-20% range cited in that trial setting), glycemic secondary measures, additional energy-expenditure interest from glucagon-receptor activity versus dual agonists.

Mechanism of Action

Simultaneous incretin and glucagon-receptor engagement is studied for energy expenditure, appetite signaling, and glycemic markers. Glucagon-receptor activity is a differentiator versus dual GIP/GLP-1 agonists.

Molecular Information

Weight
~4114 g/mol (free base, approximate)
Length
Long-acting triple agonist peptide
Type
Triple GIP/GLP-1/glucagon agonist
Formula
Amino Acid Sequence Triple incretin agonist (GLP-1/GIP/glucagon analog); full primary structure on certificate.

Research directions

Obesity trials Phase 2 published

  • Body-weight and metabolic endpoints in NEJM 2023

Glycemia Trial setting

  • Glucose-related secondary measures

Pharmacokinetics

Peak days (long-acting peptide, clinical PK)
Half-life ~6 days (reported clinical)
Cleared weeks-scale washout in trials

Clinical PK from development trials, not a use schedule.

Literature

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