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CJC-1295 without DAC

GHRH analogue (DAC and non-DAC forms)

Injectable 1mcg, Once weekly, same day each week Once weekly PHARMACOLOGY

Overview

What is CJC-1295 without DAC?

CJC-1295 is a tetrasubstituted GHRH analogue. Drug-affinity complex (DAC) versions extend half-life via albumin binding; non-DAC (“Mod GRF 1-29”) versions are shorter-acting. Catalog SKUs may list either. All catalog material is for laboratory research use only.

Key Benefits

GHRH(1-29) analogue, DAC vs non-DAC kinetics, GH/IGF-1 axis research

Mechanism of Action

GHRH-receptor activation on somatotrophs increases GH transcription and release. DAC chemistry changes duration, not the core receptor.

Quick Start Guide

Typical Dose 1mcg, Once weekly, same day each week
How Often Once weekly, same day each week
Where to Inject Abdomen, Love handles (adipose tissue preferred)
Injection Timing Any time of day, with or without food
Effects Timeline —
Storage Lyophilized (powder): room temperature or refrigerate, up to 2 years. Reconstituted: refrigerate, use within 30 days.
Cycle Length —
Break Between —

Molecular Information

Weight: 3367.9 g/mol
Length: 34 amino acids
Type: Growth Hormone-Releasing Hormone Analog with Drug Affinity Complex (CJC-1295 with DAC)
Formula: C152H252N44O42

Amino Acid Sequence

Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 (Mod GRF 1-29)

Research directions

GH axis Pharmacology

Sustained IGF-1 in DAC papers

Pharmacokinetics

Peak hours (non-DAC) / days (DAC literature)

Half-life ~30 min analogue vs days with DAC

Cleared hours vs many days

Two very different kinetic families share this name.

Literature

Teichman et al., CJC-1295 — 2006 · Clinical PK. DAC analogue prolonged GH/IGF-1.