peptides-pro
Journal
2,940 articles
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Phosphoantigen-driven dissociation of butyrophilin oligomers activates γδ T cells
Γδ T cells represent a promising avenue for cancer immunotherapy. The Vγ9Vδ2 T-cell receptor (TCR), which is e...
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Mechanism of K63-linked polyubiquitin recognition and cleavage by the BRCA1-A complex
How the BRCA1-A complex finds and removes ubiquitin signals at DNA breaks remains unknown. Here the authors sh...
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A ubiquitin chain-feeding mechanism for BRCA1-A
The BRCA1-A complex cleaves K63-linked polyubiquitin chains at DNA damage sites to control DNA repair. Here, t...
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Structure of NHE6 and its lipid-mediated interactions regulating endosomal pH
The sodium-proton exchanger NHE6 localises to endosomal membranes and mutations in the protein are known to ca...
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PA200 modulates immunoproteasome structure and activity
Proteasomes help cells recycle proteins and shape immune responses. Here, the authors show that PA200 binds st...
- Integrative structural analysis of human endosomal NHE6 reveals a lipid-associated gate and disordered C-terminus The endosomal Na+ /H+ exchanger HsNHE6 regulates organellar pH and is implicated in neurological disease. Here...
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How ocean enzymes are providing access to understudied cannabinoids
The berberine-bridge-like (BBE-like) enzyme family catalyzes diverse chemical transformations, including the f...
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PA200 modulates immunoproteasome structure and activity
Proteasomes help cells recycle proteins and shape immune responses. Here, the authors show that PA200 binds st...
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Blood metabolomic signatures linking air pollution to lung cancer in the Cancer Prevention Studies
Exposure to ambient air pollution is an established risk factor for lung cancer. In here, the authors report m...
- A flexible repertoire of wound closure strategies precedes whole-body regeneration Animals capable of whole-body regeneration can heal virtually any wound. Here they show that Hofstenia miamia...
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Uncovering the role of chromatin organization and dynamics in heart disease
Two studies published in Science explore how 3D chromatin organization and structure can influence cardiac dev...
- Chronic conditions and aortic disease risk: a prospective cohort study with predictive and etiological analyses This study shows that multimorbidity and several chronic conditions, including cardiovascular, respiratory and...
- A humanized anti-TNFR1 nanobody antagonist targeting the CRD3 region suppresses inflammation and necroptosis in vitro Humanized TNFR1-targeting nanobodies selectively block inflammatory and necroptotic signaling in vitro, offeri...
- A modular self-assembling peptide platform targeting TGF-β1 for tendon regeneration Excessive TGF-β1 activity contributes to tendon degeneration and fibrosis. Here, authors develop a self-assemb...
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Triglyceride–glucose index, neutrophil-to-lymphocyte ratio, and high-sensitivity C-reactive protein across albuminuria stages in type 2 diabetes
Diabetic kidney disease (DKD) is a major microvascular complication of type 2 diabetes mellitus (T2DM) and a l...
- Adipose-derived regenerative cells attenuate diminished ovarian reserve in a rat model: evidence for the involvement of oxidative stress and ferroptosis Diminished ovarian reserve (DOR) involves reduced oocyte quantity and quality, leading to endocrine and reprod...
- High fructose corn syrup and apple juice intakes are associated with incident asthma, the early childhood longitudinal study High fructose corn syrup (HFCS) and apple juice contain high unpaired fructose (≥ 55%), which exceeds pediatri...
- Steroid formulation, standardized prednisolone-equivalent dose, and thyroid–adrenal axis function in 28,695 adults: a real-world cross-sectional study Exogenous steroid misuse is an increasingly recognized public health concern with potential consequences for h...